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liao ning han zu guang xi zhuang zu hif-1 ji yin duo tai xing ji fa yi xue yi yi
Author(s): 
Pages: 64-65
Year: Issue:  1
Journal: Journal of Forensic Medicine

Abstract:  缺氧诱导网子1(hypoxia-inducible factor 1,HIF-1)是特异性缺氧状态下发挥活性的一种转录因子,由Semenza等[1]在缺氧的肝癌细胞株Hep3B的核提取物中首次发现.HIF-1由α亚基和β亚基组成异二聚体.HIF-1α为HIF-1唯一功能亚单位,缺氧条件下可以调控70多个与疾病有关基因的转录和表达.
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