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Association between mild cognitive impairment and neprilysin gene rs3736187 polymorphism
Author(s): 
Pages: 120-123
Year: Issue:  3
Journal: Acta Academiae Medicinae Shandong

Keyword:  Cognition disordersPolymorphismsingle nucleotideNeprilysin gene;
Abstract: 目的分析轻度认知功能障碍(MCI)患者脑啡肽酶基因(NEP)rs3736187位点单核苷酸多态性,为MCI的防治提供理论依据。方法参照美国精神病学会的精神障碍诊断和统计手册第4版(DSM-IV)的MCI诊断标准,应用聚合酶链反应-限制性片段长度多态性技术检测NEP基因多态性,采用病例-对照的关联分析方法,对NEP基因rs3736187位点进行基因型和等位基因频率分析。结果NEP基因型频率和等位基因频率分布,MCI组与对照组间差异显著(P<0.05),T等位基因携带者出现MCI的危险性高于C等位基因携带者(OR=2.212,P<0.05),NEP基因基因型频率和等位基因频率分布,男性之间和女性之间差异不明显,女性MCI组与对照组间等位基因频率分布差异显著(P<0.05)。结论NEP基因的T等位基因可能是MCI的危险因素之一,在女性MCI的发病中可能起重要作用。
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