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Relevance between peripheral endothelial progenitor cells and hepatic artery-portal vein shunting in primary hepatic carcinoma
Author(s): 
Pages: 87-90
Year: Issue:  4
Journal: Acta Academiae Medicinae Shandong

Keyword:  Endothelial progenitor cellsLiver neoplasmsHepatic artery-portal vein shuntingFlow cytometry;
Abstract: 目的探讨外周血内皮祖细胞(EPC)水平与原发性肝癌肝动-门静脉瘘(HA-PVS)形成的相关性。方法用流式细胞术测定20例健康对照组,22例慢性乙型肝炎组,30例无HA-PVS的肝癌组,28例有HA-PVS的肝癌组患者外周血EPC的水平。结果有瘘肝癌组患者外周血EPC占淋巴细胞的比例为(21.09±2.79)‰,无瘘肝癌组(12.72±3.05)‰,慢性乙型肝炎组(3.53±2.11)‰,健康对照组(2.98±2.64)‰。与健康对照组和慢乙肝组比较,两肝癌组EPC水平均升高,差异均有统计学意义(P<0.01)。有瘘肝癌组中,EPC升高更明显(P<0.01),块状型肝癌、自发性细菌性腹膜炎和门脉栓塞的发生率高,均与无瘘肝癌组存在统计学意义(P=0.031,P=0.036,P=0.044)。结论外周血EPC水平与原发性肝癌HA-PVS的形成有关,并能反映肝癌的类型、转移和预后。
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