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Effect of daunorubicin combined with cytarabine chemotherapy on the functions of islet β-cells
Author(s): 
Pages: 7-9,13
Year: Issue:  2
Journal: Acta Academiae Medicinae Shandong

Keyword:  DaunorubicinIslet β-cellsDiabetesLeukemianonlymphocyticacute;
Abstract: 目的观察柔红霉素联合阿糖胞苷化疗对胰岛β细胞功能的影响。方法选择初诊急性非淋巴细胞白血病(ANLL)患者27例,采用标准DA(柔红霉素+阿糖胞苷)化疗方案,化疗2个周期。所有患者化疗前后均行胰岛素释放试验,观察化疗前后患者血糖均值、胰岛素均值、血糖曲线下面积、胰岛素曲线下面积及胰岛β细胞功能指数的变化。结果化疗后,患者血糖曲线各点血糖均值较化疗前有所增高,其中以空腹、0.5 h、1 h增高明显(P<0.05);胰岛素曲线各点胰岛素均值较化疗前有所减少(P<0.05);血糖曲线下面积较化疗前明显增大(P<0.05),胰岛素曲线下面积较化疗前减小(P<0.05),胰岛β细胞功能指数较化疗前降低(P<0.05)。结论柔红霉素联合阿糖胞苷对非糖尿病白血病患者的胰岛β细胞有一定的损伤,有可能导致糖尿病的发生。
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