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Association of serum soluble CD40 ligand and carotid atherosclerosis in type 2 diabetics with acute cerebral infarction
Author(s): 
Pages: 27-29,43
Year: Issue:  3
Journal: Acta Academiae Medicinae Shandong

Keyword:  Type 2 diabetes mellitusCerebral infarctionCD40 ligandCarotid artery diseaseAtherosclerosis;
Abstract: 目的观测2型糖尿病合并急性脑梗死(DACI)患者血清可溶性CD40配体(sCD40L)水平变化及颈动脉粥样硬化特点,探讨血清sCD40L水平与颈动脉易损斑块的相关性。方法本实验分为糖尿病合并急性脑梗死组(DACI组,n=69)、单纯糖尿病组(DM组,n=32)和健康对照组(NC组,n=28)。3组研究对象均应用酶联免疫法测量血清sCD40L的水平,常规生化检测空腹血糖(FBG)、血脂、糖化血红蛋白(HbA1c)。并行彩色多普勒检查,测定颈动脉内-中膜厚度(IMT)、有无斑块及计算Crouse积分。根据超声结果将DACI组分为稳定斑块组、不稳定斑块组。结果3组之间血清sCD40L水平、IMT、斑块检出率、Crouse积分差别有统计学意义(P<0.05)。DACI组以不稳定斑块为主,且不稳定斑块组血清sCD40L水平高于稳定斑块组(P<0.05)。相关分析显示,血清sCD40L水平与IMT(r=0.733,P<0.01)、Crouse积分(r=0.645,P<0.01)、HbA1c(r=0.272,P<0.05)、甘油三酯(r=0.276,P<0.05)均呈显著正相关。结论血清sCD40L促进2型糖尿病患者颈动脉粥样硬化,其水平升高可能反应颈动脉粥样斑块的不稳定性。
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