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A comparative study on the efficacy and adverse reactions of two different dosages of adrenocorticotropic hormone therapy for infantile spasms
Author(s): 
Pages: 100-104
Year: Issue:  2
Journal: Acta Academiae Medicinae Shandong

Keyword:  SpasmsinfantileCorticotropinEpilepsy;
Abstract: 目的采用回顾性对照实验评价两种不同剂量促肾上腺皮质激素(ACTH)治疗婴儿痉挛(West综合征)的疗效和不良反应。方法78例婴儿痉挛患儿纳入研究,其中小剂量组42例患儿(隐源性13例,症状性29例),给予ACTH1IU/(kg.d)静滴治疗;常规剂量组36例患儿(隐源性10例,症状性26例),给予ACTH25IU/d静滴治疗,疗程均为4周,4周后对其临床疗效、脑电图改变、不良反应等进行对比分析。同时应用Logistic回归对可能影响疗效的因素进行分析。结果小剂量组与常规剂量组有效率分别为71.4%和61.1%(P>0.05),脑电图缓解率分别为69.0%和63.9%(P>0.05),不良反应发生率分别为14.3%和38.9%(P<0.05),疗效与病因及病程显著相关(P<0.05),隐源性与症状性有效率分别为86.3%和57.1%(P<0.05),病程小于等于1月者与大于1月者有效率分别为79.4%和54.5%(P<0.05)。结论小剂量ACTH短期疗效明显,不良反应少,患儿耐受性良好,可以在临床上推荐应用。
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