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Expression of DC-LAMP and DC-SIGN on Dendritic cells in Psoriasis vulgaris
Author(s): 
Pages: 136-138
Year: Issue:  4
Journal: Acta Academiae Medicinae Shandong

Keyword:  PsoriasisDendritic-cells lysosomal-associated membrane proteinDendritic-cell specific ICAM-3 grabbing non-integrin;
Abstract: 目的检测寻常型银屑病皮损中树突细胞溶酶体相关膜蛋白(DC-LAMP)、树突细胞特异性非整合素(DC-SIGN)的表达,探讨其在银屑病发病机制中的作用。方法采用免疫组化SP法检测DC-LAMP、DC-SIGN在寻常型银屑病皮损与正常皮肤的表达。结果DC-LAMP在银屑病表皮角质形成细胞(KC)基底层和棘层以及真皮树突细胞(DC)均高表达,在正常皮肤表皮KC基底层和真皮DC中呈低表达(P<0.01);DC-SIGN在银屑病表皮KC和真皮DC中均高表达,在正常皮肤表皮KC基底层和真皮DC中低表达(P<0.01)。结论寻常型银屑病发病与DC-LAMP、DC-SIGN有关。DC、KC可能通过表达DC-LAMP和DC-SIGN发挥抗原递呈作用,参与银屑病免疫发病过程。
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