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Investigation of expression of ABH and Lewis blood group antigens and their relationship to the biological behaviors of primary lung cancer
Author(s): 
Pages: 124-129
Year: Issue:  4
Journal: Acta Academiae Medicinae Shandong

Keyword:  Lung neoplasmsABH antigenLewis antigenNeoplasm metastasis;
Abstract: 目的探讨原发性肺癌组织中ABH及Lewis组织-血型抗原表达与肺癌生物学行为的相关性。方法采用免疫组织化学SP法,检测30例正常肺组织、143例原发肺癌及相应41例转移灶中ABH与Lewis血型抗原的表达。结果A、B、AB、O(H)血型瘤体抗原阳性率分别为49.02%、55.56%、35.00%、69.44%,各血型间抗原表达无统计学差异(P>0.05),Lewisa、sialylLewisx在癌组织中的表达率高于正常肺组织(P=0.045,P=0.015)。低分化癌组织ABH缺失、Lewisa、sialylLewisx表达均高于中高分化癌组织(P<0.001)。转移组ABH抗原表达缺失、sialylLewisx抗原表达均高于未转移组(P=0.004,P<0.001),转移灶ABH抗原表达缺失、sialylLewisx抗原表达高于原发癌(P<0.001)。ABH、sialylLewisx表达与未表达组5年生存率分别为32%、6%﹙P<0.001),7%、30%(P=0.0012)。结论原发肺癌组织中存在ABH及Lewis相关抗原的异常表达;ABH血型抗原表达缺失和sialylLewisx表达增加与肺癌转移相关;Lewisa、sialylLewisx抗原异常表达与肺癌组织分化程度有关;ABH及sia-lylLewisx抗原检测对预测患者预后有重要意义。
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