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Effects of resistant starch on intestinal function and aberrant crypt foci during the development of rat colorectal cancer induced by Azoxymethane
Author(s): 
Pages: 23-26
Year: Issue:  4
Journal: Acta Academiae Medicinae Shandong

Keyword:  Resistant starchColorectal neoplasmsAberrant Crypt FociRatsWistar;
Abstract: 目的研究抗性淀粉(RS)对结(直)肠癌大鼠的肠道功能及变性隐窝病灶(ACF)的影响。方法将50只雄性Wistar大鼠随机分为阴性、阳性对照组及RS低、中、高剂量组。阳性对照组大鼠从实验第2周开始腹腔注射氧化偶氮甲烷(AOM),每周1次,连续2周。阴性对照组注射生理盐水。RS各剂量组致癌剂处理同阳性对照组,并分别自由摄食含7.6%、15.2%及22.8%RS的饲料。阴性和阳性对照组大鼠摄食普通饲料。实验期间每周称重1次,于第5周末和第7周末分别进行粪便pH及排便实验。第16周断头处死所有大鼠,取出结肠组织进行指标ACF的测定。结果与阳性对照组相比,RS各剂量组ACF数目、肠道转运时间(GTT)均明显减少(P<0.01),粪便pH也有所下降(P<0.05),差异有统计学意义。结论RS有利于肠道内的环境健康,降低ACF的发生,可能是预防结(直)肠癌发生的机制之一。
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