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Role of Fn14 in myocardial fibrosis in spontaneous hypertension rats and the intervenient role of perindopril
Author(s): 
Pages: 38-43
Year: Issue:  2
Journal: Acta Academiae Medicinae Shandong

Keyword:  Fibroblast growth factor-inducible 14Spontaneous hypertension ratMyocardial fibrosisPerindoprilModlesanimal;
Abstract: 目的探讨成纤维细胞生长因子诱-导早期反应蛋白14(Fn14)在自发性高血压大鼠心肌纤维化中的作用及培哚普利的干预结果。方法18只6周龄雄性自发性高血压大鼠(SHR)随机分为高血压组(SHR-C组)和培哚普利组(SHR-P组),每组9只;另取9只同龄雄性Wistar Kyoto大鼠作为正常组(WKY组),SHR-P组给予培哚普利治疗24周。实验前后测量室间隔及左室后壁背向散射积分平均强度(AII)、校正的声学强度(CAI)与峰峰强度(PPI)等超声心动图指标。24周后,处死大鼠,测量心脏重量指数(HWI),masson染色检测胶原的表达,免疫组化法检测Fn14的表达。结果30周龄时,与WKY组相比,SHR-C组HWI显著升高、Fn14表达增高(P均<0.01),室间隔及左室后壁AII、CAI明显增大(P均<0.01),PPI明显减小(P<0.01);与SHR-C组相比,SHR-P组HWI显著降低、Fn14表达降低(P均<0.01),室间隔及左室后壁AII、CAI减小(P<0.05),PPI增大(P<0.05)。Fn14表达量与胶原纤维的量呈正相关(r=0.954,P<0.01)。结论Fn14可能参与SHR心肌纤维化,培哚普利可能通过抑制其表达来减轻心肌纤维化。
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