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Changes of microalbuminuria and serum high molecular weight-adiponectin in hypertensive patients with metabolic syndrome
Author(s): 
Pages: 78-82
Year: Issue:  4
Journal: Acta Academiae Medicinae Shandong

Keyword:  Essential hypertensionMetabolic syndromeMicroalbuminuriaHigh molecular weight-adiponectin;
Abstract: 目的比较伴代谢综合征(MS)高血压患者与单纯高血压患者的微量白蛋白尿(MAU)及高分子量脂联素(HMW-ADP)水平的差异,探讨MAU与HMW-ADP的相关性及二者与伴MS高血压的关系。方法68例原发性高血压患者,根据有无MS分为伴MS高血压组(33例)与单纯高血压组(35例)。采用放射免疫分析法测定尿白蛋白/肌酐比(ACR),双抗体夹心ELISA法测定血清HMW-ADP。结果同单纯高血压组相比,伴MS高血压患者的尿ACR增高,血清HMW-ADP降低(P<0.01);Pearson相关分析显示,血清HMW-ADP与尿ACR差异无统计学意义(P>0.05);多因素BinaryLogistic回归分析显示,空腹血糖(FPG)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、ACR及HMW-ADP与高血压患者MS的发生具有关联性(P<0.05或0.01)。结论MS加重高血压患者肾功能损害;尿ACR与血清HMW-ADP没有明显相关性;尿ACR增高及血清HMW-ADP降低可促进高血压患者MS的发生。
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