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Genotypes and related factors of hepatitis C virus in patients infected with HCV in the Shandong area
Author(s): 
Pages: 140-141,145
Year: Issue:  2
Journal: Acta Academiae Medicinae Shandong

Keyword:  Hepatitis C virusHepatitis C virus RNAGenotype;
Abstract: 目的探索山东地区丙型肝炎病毒(HCV)基因分型及其相关关系。方法采用基因芯片技术检出了448例HCV感染者的血清HCV基因型,同时检测了其中388例血清HCV RNA的含量,并对HCV基因型与HCV感染者的性别、年龄和HCV RNA含量进行了相关性分析。结果检测到4种基因亚型(1a、1b、2a、3b),呈8种组合;其中1b和2a亚型多见,分别占61.2%(274例)和32.8%(147例)。Logistic多因素分析表明,基因1b型与HCV高病毒载量独立相关。结论山东地区HCV基因分型以1b型为主,且与HCV高病毒载量相关。
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