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Experiment on lornoxicam-loaded solid lipid nanoparticles
Author(s): 
Pages: 155-159
Year: Issue:  4
Journal: Acta Academiae Medicinae Shandong

Keyword:  LornoxicamNon-steroid anti-inflammatory drugSolid lipid nanoparticlesSolvent diffusion method;
Abstract: 目的制备氯诺昔康固体脂质纳米粒(Lnxc-SLNs)并考察其理化性质。方法采用溶剂扩散法制备Lnxc-SLN,在单因素考察的基础上,采用正交试验设计优化纳米粒的处方与工艺;透射电镜下观察其外观形态,激光散射测定Zeta电位与粒度分布,低温高速离心法分离SLNs与未包封的药物,紫外分光光度法(UV)测定其包封率与载药量,膜动态透析法探讨Lnxc-SLNs的体外释药特性。结果正交试验设计优化的最佳处方与工艺:药脂比为1∶10,单硬脂酸甘油酯与大豆磷脂比为1.5∶1,表面活性剂泊洛沙姆188与吐温80分别为1.2%和0.4%,油水相之比为1∶5;纳米粒外观形态圆整,呈类球形实体粒子,平均粒径为185.3nm,Zeta电位为(-27.65±0.91)mV,包封率为(86.24±3.39)%,载药量为(8.62±0.34)%,在pH6.8PBS中释药符合双相动力学方程。结论SLNs体外释放有明显的缓释作用,是静脉注射给药有前景的靶向载体。
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