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Impact of chronic arsenic poisoning on the dentate gyrus ultra-structure and the learning and memory of the adult mouse
Author(s): 
Pages: 34-38
Year: Issue:  3
Journal: Acta Academiae Medicinae Shandong

Keyword:  Arsenic poisoningMaze learningMemoryDentate gyrusMice;
Abstract: 目的观察慢性砷中毒对小鼠海马齿状回超微结构的改变及小鼠学习记忆的影响。方法选取健康成年昆明小鼠80只,雌雄各半,分为对照组、慢性砷中毒低、中、高剂量组,每组20只,各染砷组分别以蒸馏水、1/5LD50、1/10LD50、1/40LD50As2O3灌胃,连续3个月,根据其体重变化随时调整用药剂量。灌胃结束后,采用Y-电迷宫检测各组小鼠学习记忆行为,透射电镜观察齿状回细胞超微结构的变化。结果高剂量砷中毒组学习、记忆的Y-迷宫测试次数明显高于对照组(P<0.05),电镜下观察中毒组齿状回神经元,可见部分神经细胞膜皱缩,胞体减小,核染色质电子密度增高。结论慢性砷中毒明显损害成年小鼠学习记忆的能力,可能与海马齿状回神经元受损有关。
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