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Expression and significance of cyclin D1,cyclin E and p27 in transitional cell carcinoma of the renal pelvis
Author(s): 
Pages: 109-112
Year: Issue:  4
Journal: Acta Academiae Medicinae Shandong

Keyword:  Transitional cell carcinoma of renal pelvisCyclin D1Cyclin Ep27Immunohistochemistry;
Abstract: 目的探讨细胞周期素D1(cyclinD1)、细胞周期素E(cyclinE)及p27在肾盂移行细胞癌中的表达及意义。方法选择肾盂移行细胞癌手术切除标本63例,WHO(1998)病理分级:G112例、G240例、G311例;UICC(1997)TNM病理分期:Ta4例、T19例、T224例、T317例、T49例。11例因外伤切除正常肾盂组织作为正常对照组。应用免疫组化二步法检测组织中cyclinD1、cyclinE和p27的表达。结果正常肾盂组织中,cyclinD1呈弱表达,cyc-linE不表达,p27呈高表达;肾盂移行细胞癌组织中,cyclinD1与cyclinE表达显著增高(P<0.05),p27表达显著降低(P<0.05)。随病理分级及分期的增高,cyclinD1与cyclinE的阳性表达率升高(P<0.05),p27的阳性表达率下降(P<0.05),且cyclinD1、cyclinE均与p27的表达呈负相关(P<0.05)。结论肾盂移行细胞癌组织中可见cyclinD1、cyclinE的过度表达及p27的失活,三者的联合检测有可能作为判断肾盂移行细胞癌恶性程度和预后的生物学指标。
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