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Clinical applications of ibuprofen in preterm infants with patent ductus arteriosus
Author(s): 
Pages: 523-526,534
Year: Issue:  9
Journal: World Clinical Drugs

Abstract: 早产儿动脉导管未闭(PDA)是临床早产儿的常见病症,应早期积极治疗.目前药物关闭仍是最有效、方便和经济的治疗方法.过去20多年,吲哚美辛一直是内科保守治疗的主要方法,其PDA关闭率为46%~89%,但吲哚美辛有效血药浓度安全范围较窄,且可导致肾功能障碍、颅内出血、坏死性小肠结肠炎和肠穿孔等严重不良反应,严重高胆红素血症患儿更是禁用吲哚美辛.近年国外采用布洛芬治疗早产儿PDA.取得较好疗效,关闭率为...
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