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The role of stress in depression and new drug development
Author(s): 
Pages: 557-561
Year: Issue:  9
Journal: World Clinical Drugs

Keyword:  应激下丘脑-垂体-肾上腺轴抑郁神经递质海马神经再生;
Abstract: 重度抑郁症是全球范围内最大的公共卫生难题之一,其具有反复性和周期性.可严重影响患者正常的工作能力和社会活动.应激是指外界刺激影响机体内环境稳态而引起的机体非特异性反应,长期的慢性应激通过激活并损伤下丘脑一垂体.肾上腺(HPA)轴及抑制海马神经元再生诱发抑郁症.本文就应激、HPA轴在抑郁发病机制中的重要作用以及与该杌制相关的抗抑郁药的研究进展进行综述.
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