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Effect of melatonin on the content of forebrain Dopa and its metabolic in Parkinson′s disease rats
Pages: 469-472
Year: Issue:  6
Journal: Journal of Zhenjiang Medical College

Keyword:  MelatoninN-methyl-4-phenyl-1236-tetrahydropyridine(MPTP)Dopamine(DA)Parkinson′s disease(PD);
Abstract: Objective:To study the effect of melatonin on the content of forebrain Dopa and its metabolics in Parkinson′s disease(PD) rats.Methods: Rats were divided into 5 groups: Blank,no melatonin treated group and 1mg/kg,5mg/kg,10mg/kg melatonin treated group(N=12 respectively).The model of PD was made by intraperitoneal injection of MPTP.The pole-slide test and "T"-maze test were used to evaluate PD rat′s movement disorder and its dsygnosia.The level of dopamine(DA),3,4dihydroxy phenyl ascetical acid(DOPAC),and homovanillic acid(HVA) in forebrain were detected by high performance liquid chromatography and electrochemical detection(HPLC-EC). Results: PD rats were suffered from severe movement disability and dementia.The contents of DA,HVA,dan DOPAC of forebrain in groups treated by melatonin was significantly higher than that of the untreated,though significantly lower than blank one. Conclusion: By the ant oxidative stress activities,Melatonin may regulate nervous activity and metabolism pathways of DA to improve PD symptoms.
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