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Effect of Isoflurane on the cerebral oxygensupply-demand during cardiopulmonary bypass
Pages: 443-445
Year: Issue:  5
Journal: Journal of Zhenjiang Medical College

Keyword:  IsofluraneCardiopulmonary bypassCerebral oxygen supply-demands balance;
Abstract: Objective: To observe the effect of isoflurane on the cerebral oxygen supply-demands balance during cardiopulmonary bypass(CPB).Methods: All of 24 patients undergoing heart valve replacement were randomly divided into control group and isoflurane group,12 cases each.During CPB,Isoflurane group inhaled 0.5%~3% isoflurane through oxygenator,and control group was without inhalation of isoflurane.Jugular bulb blood oxygen saturation(SjO_2)and cerebral oxygen extraction rate(CEO_2) and artery blood gas analysis were measured at five stages(T_1-T_5) of CPB: before CPB(T_1);bring down the temperature to 32℃(T_2);cooling stability stage(T_3);recovery temperature to 32℃(T_4);10min after CPB. Results: SjO_2 at T_3 was higher significant than at T_1(P<0.05) in isoflurane group.CEO_2 at point T_3 in control group and CEO_2 at point T_2 to T_3 in isoflurane group was markedly higher than that at T_1(P<(0.05));At 32 ℃(T_4),CEO_2 of isoflurane group at T_4 was markedly higher than that of control group(P<0.05). Conclusion: Isoflurane could prevent the imbalance of cerebral oxygen supply and demand during CPB.
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