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Dynamic changes of the serum CRP and prealbumin following cerebral injury and their clinical significances
Author(s): 
Pages: 430-432
Year: Issue:  5
Journal: Journal of Zhenjiang Medical College

Keyword:  cerebral injuryC-reactive protein(CRP)prealbumin(PA);
Abstract: Objective: To investigate the relationship between the changes of serum CRP and PA(prealbumin) and cerebral injury.Methods: The enrolled 95 patients were divided into three groups according to the GCS score.There were 41 cases in the mild group,25 cases in the moderate group and 29 cases in the severe group.The technique of liquid phase immunoprecipitation was used to measure the serum CRP and PA.The CRP and PA were measured 1,3,7,14 days after injury respectively.Also the 95 cases were divided into two groups: better-recovered group and worse-recovered group,according to the GCS score two weeks after injury. Results: The serum CRP content of moderate and severe group increased on the first day after injury,and reached the top level on the third day,while that of mild group only increased on the third day.The content of CRP in severe group was higher than that in moderate or mild group respectively(P<0.05),also it was higher in moderate group than that in mild group(P<0.05).All the PA contents were in the normal range.The PA level on the third day of the mild group was much higher than that of moderate and severe group respectively(P<0.01).Meanwhile the PA level of the mild group on the seventh day was also much higher than that of the severe group(P<0.05).The CRP levels of better-recovered group on the 1,3,7,14 days following injury were much lower than those of worse-covered group respectively.(P<0.01).But there was no significant difference of the PA level between these two groups. Conclusion: Dynamic changes of serum CRP level was a more valuable factor for management and prognostic prediction of cerebral injury than PA.
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