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The Clinical Significance of Detection of EGFRmRNA Expressions in Peripheral Venous Blood of the Patients with NSCLC
Pages: 36-38,41
Year: Issue:  5
Journal: Journal of Zhenjiang Medical College

Keyword:  EGFRNon small cell lung cancerMicrometastasisFluorescent quantitation PCR;
Abstract: Objective: To evaluate the clinical significance of expressions of EGFR mRNA in the peripheral blood of patients with non small cell lung cancer(NSCLC) for diagnosing micrometastasis.Methods:Fluorescent quantitation PCR was used to explore the expressions of EGFR mRNA in peripheral blood samples from 42 patients with NSCLC and 18 patients with benign pulmonary lesion.Results:The positive expression of EGFR mRNA was 45.2%(19/42) in peripheral blood of patients with NSCLC.Non of patients with benign pulmonary disease had positive expression of EGFRmRNA.Positive rates of EGFRmRNA in stage Ⅰ~Ⅱ and Ⅲ NSCLC patients was 18.75% and 58.82% respectively.Conclusion:The expressions of EGFR mRNA in peripheral blood can be used as diagnostic biomarkers of micrometastasis in patients with NSCLC.
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