Expressions of Survivin and E-cadherin in tissues of concurrent carcinomas of esophagus and gastric cardia from same patient
Author(s): LI Shaohua, DING Guangcheng, WANG Lidong, LI Xuemin, CHANG Fubao, LI Jilin, FAN Zongmin
Pages: 764-766,781
Year: 2009 Issue: 10
Journal: China Journal of Cancer Prevention and Treatment
Keyword: neoplasms; multiple primary; esophageal neoplasms; cardia; microtubule-associateal proteins; cadherins;
Abstract: OBJECTIVE:To study the characteristics of the alteration of Survivin and E-cadherin protein expressions in concurrent carcinomas of the esophagus and gastric cardia from the same patient(CC).METHODS:Survivin and E-cadherin protein expressions were detected by immunohistochemical method(ABC) in 15 patients with concurrent esophageal squamous cell carcinoma(SCC) and gastric cardia adenocarcinoma(GCA).RESULTS:In 15 CC patients,the positive immunostaining for Survivin and E-cadherin protein expressions was observed both in SCC and GCA tissues with different degrees.The positive immunostaining rate for Survivin was 71%(10/14) in SCC,and 33%(5/15) in GCA;the abnormal expression rate for E-cadherin was 93%(13/14) in SCC,and 93%(14/15) in GCA.The high coincidence rates for Survivin and E-cadherin were observed in SCC and GCA from the same patient,and accounted for 58%(8/14) and 86%(12/14),respectively.CONCLUSION:The possibility of similar molecular basis and risk factors is involved in SCC and GCA.
Pages: 764-766,781
Year: 2009 Issue: 10
Journal: China Journal of Cancer Prevention and Treatment
Keyword: neoplasms; multiple primary; esophageal neoplasms; cardia; microtubule-associateal proteins; cadherins;
Abstract: OBJECTIVE:To study the characteristics of the alteration of Survivin and E-cadherin protein expressions in concurrent carcinomas of the esophagus and gastric cardia from the same patient(CC).METHODS:Survivin and E-cadherin protein expressions were detected by immunohistochemical method(ABC) in 15 patients with concurrent esophageal squamous cell carcinoma(SCC) and gastric cardia adenocarcinoma(GCA).RESULTS:In 15 CC patients,the positive immunostaining for Survivin and E-cadherin protein expressions was observed both in SCC and GCA tissues with different degrees.The positive immunostaining rate for Survivin was 71%(10/14) in SCC,and 33%(5/15) in GCA;the abnormal expression rate for E-cadherin was 93%(13/14) in SCC,and 93%(14/15) in GCA.The high coincidence rates for Survivin and E-cadherin were observed in SCC and GCA from the same patient,and accounted for 58%(8/14) and 86%(12/14),respectively.CONCLUSION:The possibility of similar molecular basis and risk factors is involved in SCC and GCA.
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