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The effect of Qianlie Granute on serum PAP and T﹠E2 in model of prostatic hyperplasia rats
Author(s): 
Pages: 335-337
Year: Issue:  3
Journal: Qianwei Journal of Medicine & Pharmacy

Keyword:  Qianlie Granute BPH PAP Sexual hormones Rats;
Abstract: Objective To study the influence of Qianlie Granute on serum prostatic-specific acid phosphatase(PAP) and T﹠E2 (testosterone & estrogen-2) in experimental model of benign prostatic hyperplasia(BPH) animals. Methods An experimental model of prostatic hyperplasia of castrated male rat (totally,40 rats;besides,10 as normal controls)induced by testosterone propionate was made, among whom 10 were model group, 30 were experiment groups; the 30 rats again divided into lower, moderate and higher dosage groups; and they were treated with Qianlie granute 2.5ml/kg,5ml/kg,10ml/kg for 5 weeks.Body weight and weight of the whole prostate were weighted so to calculate prostatic index;serum acid phosphatase(ACP),non- prostatic-specific acid phosphatase(NPAP) were measured to calculate serum PAP;serum T﹠E2 were also measured.Results The weight of the whole prostate and serum PAP were obviousbly decreased compared with the model group(P<0.01),the levels of serum T were decreased obviously with the model group(P<0.01).Conclusion Qianlie Granute could significantly inhibit the increases in serum PAP and T in model of prostatic hyperplasia rats.
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