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Effect of YQHX Mixture of CMM on expression of E-CD and invasion of human lung cancer cell lines in vitro
Author(s): 
Pages: 325-328
Year: Issue:  3
Journal: Qianwei Journal of Medicine & Pharmacy

Keyword:  Epithelial cadherin Chinese herbal medicine of YIQIHUOXUE(YQHX) Lung cancer Cell culture Invasion All-trans tretinoin acid;
Abstract: Objective To elucidate the effects of Chinese herbal medicine of YIQIHUOXUE(YQHX) on proliferation and expression of E-CD and invasion of human lung cancer cell lines:pulmonary aden-carcinoma (A549) and small cell lung cancer (NC-H446) in vitro.Methods By using cytometry, immunohistochemistry method, image technique, Boyden Chamber method authors studied the effects of YQHX or all trans-tretinoin acid(ARTA) on proliferation and expression of E-CD invasion of A549, NC-H446 cell lines with differentiation time cultured by YQHX or ARTA in vitro.Results (1)The prolife-ration of A549 or NC-H446 were inhibited significantly by 75μm/L YQHX or 10-5mmol/L ARTA(P<0.01),but there was not significant difference between YQHX and ARTA(P>0.05);the shape and structure of cell A549 or NC-H446 showed variant.(2)YQHX or ARTA enhanced remarkably expression of E-CD of A549 and NC-H446 with 36 hour cultured for 36 hours(P<0.01).(3)The quantity of two strains of cells crossed Matrigel and polyvinylpyrrolidone-free polycarbonate filter were significantly more than the con-trolled group(P<0.01);there was not significant difference between YQHX and ARTA(P>0.05). Conclusion YQHX can inhibit the proliferation and enhance expression of E-CD on A549 or NC-H446, decrease invasion and metastasis of A549 or NC-H446.
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