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Levamlodipine besylate combined with losartan in the treatment of diabetic nephrosis associated with hypertension
Pages: 282-284
Year: Issue:  3
Journal: Qianwei Journal of Medicine & Pharmacy

Keyword:  Levamlodipine besylate Losartan Diabetic nephrosis Hypertension Therapeutic effects;
Abstract: Objective To discuss the antihypertensive effects of levamlodipine besylate, losartan alone and their combined treatment in diabetic nephrosis patients with hypertension and their influence on renal function. Methods 60 patients with type 2 diabetic nephrosis complicated with hypertension divided into 3 groups ramadom: 20 cases were given levamlodipine besylate 2.5mg, once a day; 20 cases losartan 50mg, once a day and 20 cases levamlodipine besylate 2.5mg plus losartan 50mg (i.e combined treatment group), once a day; The treatment course of 3 groups were all 12 weeks. After treatment, the antihypertensive effect and change of renal function were observed.Results After treatment all 3 groups showed significant lowering of blood pressure and decrease of urine albumin excretion volume(P values all <0.01).In the combined treatment group there was more significant decreasing of urine album discharge than in the levatmlodipine besylate group or losartan group (P values all <0.01),while between the levamlodipine besylate group and losartan group there was no statistical difference (P>0.05). Conclusion The long-term treatment of levamlodipine besylate or losartan alone for diabetic nephrosis with hypertension patients can all lower the blood pressure, decrease urine albumin excretion volume, and protect the renal function,but combined use of these two agents would give better effect in protecting the renal function.
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