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Clinicopathologic analysis of renal amyloidosis: An analysis of 15 cases
Author(s): 
Pages: 272-274
Year: Issue:  3
Journal: Qianwei Journal of Medicine & Pharmacy

Keyword:  Amyloidosis Kidney Clinical pathology;
Abstract: Objective To investigate the clinicopathologic characteristics of renal amyloidosis. Methods The clinicopathologic data were collected from 15 cases of renal amyloidosis confirmed by pathology.They were retrospectively analyzed by light microscopy,histochemistry and immunofluorescense. ResultsInitially the renal manifestation was usually the nephrotic syndrome.As the disease progressed,renal insufficiency and renal failure appeared.Primary kidney amyloidosis was found in 11 cases,and secondary kidney amyloidosis in 4 cases. Histologically, amyloid material was deposited in the glomerular mesangia, glomerular basement membranes,vessel walls and interstitium.The areas affected appeared acellular or hypocellular.In advanced stages,the glomeruli were completely replaced with amyloid material and appeared acellular(3/15). Amyloid deposits were positive for Congo Red(15/15).Conclusions The etiologies of amyloidosis are barious.The diagnosis of the disease depends on its histopathology and histochemistry examination. Its clinical manifestation should also be taken into account.
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