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da shu xin zang dun xing cuo shang hou bcl-2 ctnt de biao da yu sun shang shi jian de guan xi
Author(s): 
Pages: 669-671
Year: Issue:  6
Journal: Research of Traditional Chinese Medicine

Keyword:  损伤时间心脏挫伤肌钙蛋白Tbcl-2;
Abstract: 目的探讨大鼠钝性心脏挫伤后肌钙蛋白T(cTnT)、bcl-2在心肌中的表达和损伤时间的关系。方法Wistar大鼠建立钝性心脏挫伤模型,并用常规HE染色、免疫组织化学技术(SP法)结合计算机彩色图像分析技术,观察大鼠实验性心脏挫伤后bcl-2、cTnT的染色变化及时效趋势。结果免疫组织化学染色:心脏挫伤2 h可见大鼠心肌cTnT明显脱失,随着时间延长,挫伤组cTnT脱失逐渐加重,对照组心肌中只有小面积脱失(P<0.05);对照组有少量bcl-2表达,挫伤组bcl-2表达增多,但随时间延长bcl-2表达呈递减趋势(P<0.05)。结论钝性心脏挫伤后cTnT、bcl-2可能参与了损伤灶的形成,其表达改变的时序可望作为客观指标用于法医学心肌损伤时间的推断。
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