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san qi zong zao zuo dui da shu nao chu xue hou nao xue liu ji xi bao diao wang de ying xiang
Author(s): 
Pages: 683-685
Year: Issue:  6
Journal: Research of Traditional Chinese Medicine

Keyword:  三七总皂甙脑出血脑血流细胞凋亡;
Abstract: 目的探讨大鼠实验性脑出血后脑组织局部脑血流的变化及神经细胞凋亡发生的规律,观察三七总皂甙对出血性脑损伤的保护作用。方法采用Nath改良法建立大鼠脑出血模型,氢清除法测定其局部脑血流,用末端脱氧核苷酸转移酶介导的脱氧三磷酸尿苷缺口末端标记(TUNEL)法检测细胞凋亡。结果出血后1h全脑的血流量均下降,4 h恢复至对照组水平,并维持至出血后24 h,出血后48h再次出现脑血流下降。而干预组脑血流下降不明显,但较脑出血组有统计学意义(P<0.05)。大鼠脑出血24h后脑组织TUNEL阳性细胞数表达显著增高,与脑出血模型组比较,干预组TUNEL阳性细胞数显著减少(P<0.01)。结论三七总皂甙可减轻脑出血后继发性的缺血性损害,并有抑制细胞凋亡的作用。
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