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Effect of Wenyangtongmai Decoction on MDA and SOD Levels in Ischemia-Reperfusion Myocardium
Pages: 664-665
Year: Issue:  6
Journal: Research of Traditional Chinese Medicine

Keyword:  myocardial ischemic reperfusionischemic preconditioningWenyangtongmai DecoctionSODMDA;
Abstract: Objective To study the effect of Wenyangtongmai Decoction on MDA and SOD in ischemia-reperfusion myocardium of rats.Methods Forty-eight animals were divided into 4 groups: Wenyangtongmai Decoction group(n=12),ischemic preconditioning group(IP,n=12),ischemia reperfusion group(IR,n=12) and sham-operative group(n=12).The animal models were established by ligation of LAD.The amount of the MDA and SOD were detected.Results Compared with IR group,the amount of MDA in Wenyangtongmai Decoction group and IP group were significant lower than that in IR group(P<0.05).SOD in Wenyangtongmai Decoction group and IP group were higher significantly than that in IR group(P<0.05).Conclusion Wenyangtongmai Decoction could decrease MDA and increase SOD of the ischemia-reperfusion myocardium.The result suggested that Wenyangtongmai Decoction had protective role on the myocardium with ischemia-reperfusion injury.
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