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The Relationship between Fibrinolytic System and Vascular Endothelial Function in Acute Coronary Syndrome
Author(s): 
Pages: 258-260
Year: Issue:  3
Journal: Research of Traditional Chinese Medicine

Keyword:  acute coronary syndromefibrinolysisendothelial functionbrachial artery flow mediated dilatation;
Abstract: Objective To study the relationship between the endothelium function and fibrinolysis system in patients(pts)with acute coronary syndrome(ACS).Methods There were three groups were design to study:Control group(n=42),stable angina pectoris group(SAP group,n=43)and ACS group(n=52).The brachial artery flow mediated dilatation(FMD)and nitroglycerin-induced dilatation(NID)was measured by high resolution ultrasound technique.The serum concentration of plasminogen activator inhibitor(PAI-1)and tissue-type plasminogen activator(t-PA)were measured.Results PAI-1(69.40±5.73)ng/mL in ACS group was significantly higher than that in control group and SAP group(P< 0.01),t-PA(10.57±5.15)in ACS group was significantly lower than that in control group and SAP group(P<0.01).There were no significant differences between the control group and SAP group.Vascular endothelial function(7.57±6.30)% in ACS group was significantly lower than that in control group(12.26±4.33)% and SAP group(11.25±3.08)%(P<;0.01).There were no significant differences between the control group and SAP group.There was significant negative correlation between FMD function and PAI-1 in ACS(r=-0.8115,P<0.05).The equation was Y=69.54-0.89X(P<0.05).Conclusion PAI-1 might be a blood marker of vascular endothelial function in pts with ACS.The increased PAI-1 could provide evidences for clinical diagnosis of ACS.
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