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shao yao zuo dui da shu nao que xue zai guan zhu sun shang xi bao diao wang xiang guan ji yin de ying xiang
Author(s): 
Pages: 310-312
Year: Issue:  3
Journal: Research of Traditional Chinese Medicine

Keyword:  芍药苷脑缺血再灌注损伤凋亡FasP38丝裂原活化蛋白激酶;
Abstract: 目的探讨芍药苷对大鼠局灶性脑缺血再灌注后缺血区神经元凋亡的影响。方法建立大鼠MCAO模型模拟局灶性脑缺血再灌注损伤,观察芍药苷对脑缺血再灌注损伤后动物的神经行为学评分;TUNNEL法检测神经元凋亡的数量改变;用WEST-ERBLOT法及免疫组化法检测β-P38、Fas的表达改变。结果假手术组无神经行为改变,各用药组神经行为学评分明显低于缺血再灌注组(P<0.01),用药组间无统计学意义。与假手术组相比,缺血再灌注组大鼠缺血侧脑组织TUNEL阳性细胞及Fas阳性细胞增多(P<0.01)。与模型组相比,各用药组TUNEL阳性神经细胞及Fas阳性细胞表达明显减少(P<0.01)。大鼠脑缺血再灌注后脑组织磷酸化P38蛋白表达明显增加,注射药物后蛋白磷酸化被抑制,表达减少。结论芍药苷可改变大鼠脑缺血后的神经行为,抑制P38蛋白的表达,下调Fas蛋白表达,有抗神经元凋亡作用。
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