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Effect of Puerarin on TGF-β_1 Cytokines Expression in Focal Cerebral Ischemia
Pages: 297-299
Year: Issue:  3
Journal: Research of Traditional Chinese Medicine

Keyword:  Puerarincerebral ischemiaTGF-β_1;
Abstract: Objective To study the nerve protective mechanism of puerarin on ischemic brain injured by the expression of TGF-β1 cytokines.Methods Models of brain medium-sized artery focal cerebral ischemia in one hundred and eight healthy male SD(Spraque-Dawley)rats were built with the improvement Zea-Longar patching methods.They were divided randomly into three groups:The sham operation group(n=36);the operation group(n=36)and the operation with puerarin interfered group(n=36).There were five different observing time in every group(6 h,12 h,24 h,48 h and 72 h).The rats in operation with puerarin group were treated with puerarin solution.The rats in sham operation and operation group were injected with the same volume sodium chloride.The expression of TGF-β1 cytokines in different time was observed with the method of SABA immunity histochemistry staining in ischemic region.Results ① Compared with the sham operation group,there were more expression of the TNF-α,TGF-β1 cytokines in cerebral ischemic reperfusion brain tissue in the operation and the operation with puerarin interfered groups(P<0.01).② Compared with the operation group,the expression of TNF-α cytokine was significantly decreased,while the expression of TGF-β1 cytokine was improved rapidly in different time after cerebral ischemic-reperfusion in the operation with puerarin interfered group(P<0.05 or P<0.01).Conclusion Puerarin could upregulate the level of the TGF-β1 cytokine and restrained the over inflammatory reaction to protect the nerve tissue.
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