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The Nitric Oxide,GSH-Px and Zn2+ in Cerebrospinal Fluid in Patients with Cerebrovascular Disease
Author(s): 
Pages: 390-392
Year: Issue:  5
Journal: Research of Traditional Chinese Medicine

Keyword:  cerebral hemorrhagesubarachnoid hemorrhageNOGSH-Pxcerebrospinal fluid;
Abstract: Objective To study the changes and significance of nitric oxide (NO),glutathione peroxidase (GSH-Px) and Zn2+ in cerebrospinal fluid (CSF) in patients (pts) with cerebrovascular disease.Methods The level of NO,GSH-Px and Zn2+ in CSF and osmotic pressures (OP) of CSF in pts with cerebral hemorrhage(CH) and subarachnoid hemorrhage (SAH) were tested and analyses.Results The NO level in pts with severe cerebrvasculsr diseases was higher than that in pts with mild illness(P<0.05) and its concentration in pts with mild illness was higher than that in control group(P<0.05).But the concentrations of GSH-Px and Zn2+ were opposite.The concentration of NO was negatively correlative with the concentration of GSH-Px(r=-0.57,P<0.05)in CSF.The concentration of GSH-Px was positively correlative with the concentration of Zn2+ in CSF(r=0.68,P<0.05).The level of NO in CSF in pts with high OP was higher than that with low OP(P<0.05).The level of GSH-Px was opposite(P<0.05).Conclusion The levels of NO,GSH-Px and Zn2+ could be used to evaluate the damage degree by free radicals and the ability of clearing free radicals in pts with SAH and CH.
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