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shuang gen qing nao jian ji dui xue guan xing chi dai da shu nao wei xue guan nei pi xi bao icam-1 biao da de ying xiang
Author(s): 
Pages: 882-883
Year: Issue:  10
Journal: Research of Traditional Chinese Medicine

Keyword:  内皮细胞ICAM-1血管性痴呆双根清脑煎剂;
Abstract: 目的观察双根清脑煎剂对血管性痴呆(VD)模型大鼠脑微血管内皮细胞间黏附分子(ICAM-1)表达的影响。方法采用从颈外动脉进行插管缓慢注入同种血栓栓子造成血管性痴呆大鼠模型,中药组给予双根清脑煎剂4g/(kg·d),模型组给予生理盐水4g/(kg·d)。免疫组织化学方法测定大鼠模型脑微血管ICAM-1的表达。结果与模型组相比同,无论是1d,还是3d与7d,双根清脑煎剂均能有效降低VD大鼠模型脑组织内内皮细胞ICAM-1的表达,且具有统计学意(P<0.05或P<0.05)。结论双根清脑煎剂具有下调VD大鼠模型脑微血管内皮细胞ICAM-1表达的作用。
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