Increased coagulation and fibrinolytic activities in the bile of gallstone patients
Author(s): TANG Zhaohe, QIN Yonglin, YE Shengai, ZUO Zongdao, FAN Xin, WANG Fengchen, GAO Nairong, CHEN Ju, LU Huixia, ZUO Zhenling, YANG Detong, TANG Wenhao
Pages: 93-97
Year: 2002 Issue: 1
Journal: Journal of Nanjing Railway Medical College
Keyword: cholelithiasis; cholesterol; antithrombin Ⅲ; fibrinolysis; blood coagulation;
Abstract: Objective To study the effects of coagulatic and fibrinolytic activities on production of fibrin in acalculous and calculous human gallbladder bile.Methods Coagulatic and fibrinolytic components,and D dimer antigen were studied in the gallbladder bile of patients with gallstones (26 patients) compared with those without gallstones (17 patients).Results Tissue factor concentration was higher in the bile of patients with gallstones than those without gallstones ± s ,(5.646± 1.682 )ng·L -1 ,versus(0.478±0.055)ng·L -1 , P <0.01].But there was no significant difference in the antigen of tissue factor pathway inhibitor between the two groups .But there was no significant difference in the antigen of tissue factor pathway inhibitor between the two groups ± s ,(12.52±2.11)ng·L -1 ,versus(11.67±3.24)mg·L -1 ].Prothrombin fragment F 1+2 was higher in gallstone group than that in controls .Prothrombin fragment F 1+2 was higher in gallstone group than that in controls ± s ,(40.638±6.694)nmol·L -1 ,versus(14.659±2.612)nmol·L -1 , P <0.05].Factor Ⅷ antigen was strikingly higher in gallstone group than that in controls .Factor Ⅷ antigen was strikingly higher in gallstone group than that in controls ± s ,(492.42± 151.26 )mg·L -1 ,versus(116.82±17.55)mg·L -1 , P <0.01].Fibrinogen was significantly higher in gallstone group than that in controls .Fibrinogen was significantly higher in gallstone group than that in controls ± s ,(8.340±0.886)g·L -1 ,versus(2.542±0.622)g·L -1 , P <0.01].Antithrombin Ⅲ antigen was detected in much greater concentration in the bile of patients with gallstones than those without gallstones .Antithrombin Ⅲ antigen was detected in much greater concentration in the bile of patients with gallstones than those without gallstones ± s ,(348.379±86.013)mg·L -1 ,versus(185.716±36.682)mg·L -1 , P <0.01].On the contrary, the activity of antithrombin Ⅲ was much lower than that in controls .On the contrary, the activity of antithrombin Ⅲ was much lower than that in controls ± s ,(97.06±23.47)%,versus(159.92±18.24)%, P <0.05].There was a significant difference of the ratio of AT Ⅲ:Ag to AT Ⅲ:Ac between the two groups .There was a significant difference of the ratio of AT Ⅲ:Ag to AT Ⅲ:Ac between the two groups ± s ,(7.399±1.237),versus(1.251±0.02), P <0.05].There was no significant difference in the antigen of protein C (PC) between the two groups .There was no significant difference in the antigen of protein C (PC) between the two groups ± s ,(2.749±0.962)mg·L -1 ,versus(3.271±0.664)?mg·L -1 ].The activity of plasmin was greater in the gallbladder bile of calculous patients than those of patients without gallstones .The activity of plasmin was greater in the gallbladder bile of calculous patients than those of patients without gallstones ± s ,(108.377±17.314)%,versus(32.778±8.552)%, P <0.05],and the ratio of fibrinolytic activity to coagulatic activity was much lower in patients with gallstones than in those without gallstones ,and the ratio of fibrinolytic activity to coagulatic activity was much lower in patients with gallstones than in those without gallstones ± s ,( 0.401± 0.096)%,versus(0.038±0.000?6)%, P <0.01].There was no significant difference in the activity of plasminogen activator inhibitor between the two groups .There was no significant difference in the activity of plasminogen activator inhibitor between the two groups ± s ,(0.442±0.036)%,versus(0.610±0.088)].D dimer was significantly higher in gallstones group than that in controls .D dimer was significantly higher in gallstones group than that in controls ± s ,(3.251±0.822)%,versus( 0.262± 0.025)%, P <0.01]. . Conclusion Both of the coagulatic activities and fibrinolytic activities in the bile of patients with gallstones are enhanced, but the anticoagulatic activities are not concomitantly enhanced and the increment of fibrinolytic activity w
Pages: 93-97
Year: 2002 Issue: 1
Journal: Journal of Nanjing Railway Medical College
Keyword: cholelithiasis; cholesterol; antithrombin Ⅲ; fibrinolysis; blood coagulation;
Abstract: Objective To study the effects of coagulatic and fibrinolytic activities on production of fibrin in acalculous and calculous human gallbladder bile.Methods Coagulatic and fibrinolytic components,and D dimer antigen were studied in the gallbladder bile of patients with gallstones (26 patients) compared with those without gallstones (17 patients).Results Tissue factor concentration was higher in the bile of patients with gallstones than those without gallstones ± s ,(5.646± 1.682 )ng·L -1 ,versus(0.478±0.055)ng·L -1 , P <0.01].But there was no significant difference in the antigen of tissue factor pathway inhibitor between the two groups .But there was no significant difference in the antigen of tissue factor pathway inhibitor between the two groups ± s ,(12.52±2.11)ng·L -1 ,versus(11.67±3.24)mg·L -1 ].Prothrombin fragment F 1+2 was higher in gallstone group than that in controls .Prothrombin fragment F 1+2 was higher in gallstone group than that in controls ± s ,(40.638±6.694)nmol·L -1 ,versus(14.659±2.612)nmol·L -1 , P <0.05].Factor Ⅷ antigen was strikingly higher in gallstone group than that in controls .Factor Ⅷ antigen was strikingly higher in gallstone group than that in controls ± s ,(492.42± 151.26 )mg·L -1 ,versus(116.82±17.55)mg·L -1 , P <0.01].Fibrinogen was significantly higher in gallstone group than that in controls .Fibrinogen was significantly higher in gallstone group than that in controls ± s ,(8.340±0.886)g·L -1 ,versus(2.542±0.622)g·L -1 , P <0.01].Antithrombin Ⅲ antigen was detected in much greater concentration in the bile of patients with gallstones than those without gallstones .Antithrombin Ⅲ antigen was detected in much greater concentration in the bile of patients with gallstones than those without gallstones ± s ,(348.379±86.013)mg·L -1 ,versus(185.716±36.682)mg·L -1 , P <0.01].On the contrary, the activity of antithrombin Ⅲ was much lower than that in controls .On the contrary, the activity of antithrombin Ⅲ was much lower than that in controls ± s ,(97.06±23.47)%,versus(159.92±18.24)%, P <0.05].There was a significant difference of the ratio of AT Ⅲ:Ag to AT Ⅲ:Ac between the two groups .There was a significant difference of the ratio of AT Ⅲ:Ag to AT Ⅲ:Ac between the two groups ± s ,(7.399±1.237),versus(1.251±0.02), P <0.05].There was no significant difference in the antigen of protein C (PC) between the two groups .There was no significant difference in the antigen of protein C (PC) between the two groups ± s ,(2.749±0.962)mg·L -1 ,versus(3.271±0.664)?mg·L -1 ].The activity of plasmin was greater in the gallbladder bile of calculous patients than those of patients without gallstones .The activity of plasmin was greater in the gallbladder bile of calculous patients than those of patients without gallstones ± s ,(108.377±17.314)%,versus(32.778±8.552)%, P <0.05],and the ratio of fibrinolytic activity to coagulatic activity was much lower in patients with gallstones than in those without gallstones ,and the ratio of fibrinolytic activity to coagulatic activity was much lower in patients with gallstones than in those without gallstones ± s ,( 0.401± 0.096)%,versus(0.038±0.000?6)%, P <0.01].There was no significant difference in the activity of plasminogen activator inhibitor between the two groups .There was no significant difference in the activity of plasminogen activator inhibitor between the two groups ± s ,(0.442±0.036)%,versus(0.610±0.088)].D dimer was significantly higher in gallstones group than that in controls .D dimer was significantly higher in gallstones group than that in controls ± s ,(3.251±0.822)%,versus( 0.262± 0.025)%, P <0.01]. . Conclusion Both of the coagulatic activities and fibrinolytic activities in the bile of patients with gallstones are enhanced, but the anticoagulatic activities are not concomitantly enhanced and the increment of fibrinolytic activity w
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