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Effect of CNTF and NGF on peripheral nerve regeneration in rat
Author(s): 
Pages: 16-18
Year: Issue:  1
Journal: CHINESE JOURNAL OF HAND SURGERY

Keyword:  周围神经神经再生神经生长因子;
Abstract: 目的:研究睫状神经营养因子(ciliary neurotrophic factor,CNTF)和神经生长因子(nerve growth factor,NGF)对周围神经再生的作用.方法:硅管套接大鼠坐骨神经,将CNTF、NGF、生理盐水(normal saline solution,NS)分别加入硅管中,并于术后每日皮下注射一定剂量.术后4周,应用HRP逆行追踪技术显示再生轴突通过修复部位的胞体.结果:与NS组、NGF组相比,CNTF组脊髓标记胞体显著增加,其它组间比较,差异不显著.结论:外源性CNTF能明显促进周围神经运动轴突再生,但促进感觉轴突再生的作用不明显.外源性NGF促进周围神经运动和感觉轴突的再生均不明显.
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