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sheng gan jian pi ke li dui gan xian wei hua da shu gan zang xi bao yin zi han liang de ying xiang
Author(s): 
Pages: 153
Year: Issue:  10
Journal: Journal of Liaoning College of Traditional Chinese

Keyword:  肝纤维化肝脏细胞因子升肝健脾颗粒大鼠实验研究;
Abstract: 目的:探讨升肝健脾颗粒对CCl4所致肝纤维化大鼠肝脏TNF-α和IL-1β、IL-8含量的影响。方法:建立大鼠CCl4肝纤维化模型,予以升肝健脾颗粒大、中、小剂量及秋水仙碱治疗,采用放免法检测肝脏中TNF-α和IL-1β、IL-8的含量。结果:升肝健脾颗粒大、中剂量组能显著降低受损肝脏中TNF-α和IL-1β、IL-8的含量,与阴性对照组相比有显著性差异。结论:升肝健脾颗粒通过降低细胞因子含量,而对损伤肝脏发生保护作用。
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