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Shen Fu Xiong Ze Injection: Its Effects on Hemodynamics and Cardiac myocyte Apoptosis in Experimental Pressure-Overloaded Rats
Pages: 146-148
Year: Issue:  10
Journal: Journal of Liaoning College of Traditional Chinese

Keyword:  Shen Fu xiong Ze Injection pressure-overloaded hemodynamicsapoptosis Bcl-2 Bax;
Abstract: Objective :To explore the effects of Shen Fu Xiong Ze Injection on hemodynamics and cardiac myocyte apoptosis in experimental pressure-overloaded rats. Methods :A aortic band was placed in SD rats via replication of Ohkusa etc. We measured hemodynamics by putting the tube into the left ventricles. The protein expression of Bcl-2 and Bax gene were investigated by S-P immuno-histochemial stain and image analysis system. Results :In model groups, LVSP,-LVdp/dtmax +LVdp/dtmax decreased and SBP,DBP,LVEDP increased as compared with the sham-operation group; the protein expression of Bcl-2 gene was reduced and the protein expression of Bax gene increased(P<0.05).Compared with the model group, LVSP,±LVdp/dtmax in administration groups were higher and SBP,DBP,LVEDP were lower than those of the model group(P<0.05) ;the OD value of Bcl-2 protein and the protein expression ratio of Bcl-2/Bax increased and the OD value of Bax protein decreased significantly in administration groups. Conclusions : The present study suggested that Shen Fu Xiong Ze Injection could significantly improve hemodynamics and inhibit cardiac myocyte apoptosis.
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