Author(s): WANG Ying, SHI Ruihua, LIU Jiyong, SHEN Zuo, YU Lianzhen, XU Zuo, ZHANG Xia, DING Xiafen
Pages: 8-10
Year: 2002 Issue:  4
Journal: Petrochemical Safety Technology
Keyword:  Famotidine; Pepcid Complete; Functional disorders; Randomized control trial;
Abstract: AIM To investigate efficacy and safety of Pepcid Complete(compound famotidine) on heartburn,acid related functional disorders.METHODS 229 patients with heartburn,acid related FD in different trial centers were enrolled and double-blindly,randomly prescribed either Pepcid Complete or Famotidine.Intention-to-treat(ITT),Per-Protocol and Safety Population(PP) are employed for analysis of efficacy and safety respectively.RESULTS 218,229,229 patients were enrolled PP,ITT and Safety Population respectively.No significant difference in efficacy and safety were found between Pepcid Complete and Famotidine on heartburn,acid reflux,abdominal discomfort or pain.The mean time of control heartburn and acid reflux of Pepcid Complete is shorter than that of Famotidine.There was more significant improvement in heartburn and acid reflux scores during the first treatment period in Pepcid Complete group.CONCLUSIONS Both Pepcid Complete and Famotidine are effective and safe in treatment of heartburn and acid related FD.Patients in Pepcid Complete group got sooner and longer remission than those in Famotidine group.