Mechanism Studies on Ultralow Frequency Pulsed Magnetic Field Inducing Apoptosis of Cancer Cell
Author(s): ZHANG Husheng, DENG Renqing
Pages: 13-14,4
Year: 2006 Issue: 2
Journal: Biomagnetism
Keyword: magnetic field; cancer; cell apoptosis; membrane potentials; Lorentz force; role on cellular and nuclear membrane;
Abstract: We studied the effects of ultralow frequency pulsed magnetic field(with maximum intensity of 0.6～2.0T,gradient of 10～100 T·m1,pulse width of 20～200 ms and frequency of 0.16～1.34 Hz) on S-180 sarcomas in mice.With a electron microscope,we found the programmed cell death(PCD) of the sarcoma cells.We consider the mechanism is that the pulsed magnetic field causes the change of the cellular membrane potentials,then causes the calciumion influxing,so leads to the programmed cell death.By Lorentz force the magnetic field keeps the moving ions within bounds of Larmor radius.Thus,penetrating capability of the positive and negative ions through the cellular and nuclear membrane was affected,even the role on cellular and nuclear membrane formed.
Pages: 13-14,4
Year: 2006 Issue: 2
Journal: Biomagnetism
Keyword: magnetic field; cancer; cell apoptosis; membrane potentials; Lorentz force; role on cellular and nuclear membrane;
Abstract: We studied the effects of ultralow frequency pulsed magnetic field(with maximum intensity of 0.6～2.0T,gradient of 10～100 T·m1,pulse width of 20～200 ms and frequency of 0.16～1.34 Hz) on S-180 sarcomas in mice.With a electron microscope,we found the programmed cell death(PCD) of the sarcoma cells.We consider the mechanism is that the pulsed magnetic field causes the change of the cellular membrane potentials,then causes the calciumion influxing,so leads to the programmed cell death.By Lorentz force the magnetic field keeps the moving ions within bounds of Larmor radius.Thus,penetrating capability of the positive and negative ions through the cellular and nuclear membrane was affected,even the role on cellular and nuclear membrane formed.
Related Articles