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Clinical characteristics and changes,drug resistance of pathogenic bacteria in the newborns with purulent meningitis
Author(s): 
Pages: 334-337
Year: Issue:  5
Journal: Railway Medical Journal

Keyword:  neonatepurulent meningitispathogenic bacteriadrug resistance;
Abstract: Objective To analyze neonatal purulent meningitis clinical feature,pathogenic bacterium tendency,disposition and resistance and to guide the clinical medication.Methods Clinical materials of 65 cases with purulent meningitis in neonatal were collected and analyzed retrospectively form January 2003 to December 2007.Results Fever,reject breast milk,lethargy,convulsion,cyanosis were major clinical features.65 strains were detected from cerebrospinal fluid.Gram-positive bacilli accounting for 45 strains(64%) and gram-negative bacilli accounting for 23 strains(36%).The proportion of gram-negative bacillus and E coli were increasing in total causative pathogens annually,coagulase negative staphylococcus was decreasing year by year.Gram-positive bacilli demonstrated a strong resistance to penicillin,ampicillin and was sensitive to vancomycin.Gram-negative bacillus demonstrated a strong resistance to penicillin,first-generation cephalosporin and was sensitive to imipenem,ceftriaxone and ceftazidime.Conclusion Neonatal purulent meningitis has no specificity clinical feature and pathogenic bacteria diversify.So pathogenic bacterium should be detected,and susceptibility test and rational use of antibiotic should be done in borderline case.
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