The plasma concentration of monocyte chemoattractant protein-1 and clinical significance in patients with premature heart disease
Author(s): ZHANG Luzhan, CHEN Zhong, MA Genshan
Pages: 170-173
Year: 2008 Issue: 3
Journal: Railway Medical Journal
Keyword: premature coronary heart disease; monocyte chemoattractant protein-1; acute coronary syndrome; stable angina pectoris;
Abstract: Objective To study the relationship between plasma concentration of monocyte chemoattractant protein-1(MCP-1)and patients with premature heart disease.Methods MCP-l was measured by means of enzyme linked immonosorbent assay(ELISA)in 44 patients with acute coronary syndrome(ACS),41 patients with stable angina pectoris(SAP)and 87 patients in control group.Results Plasma concentration of MCP-1 was significantly higher in ACS group than that in SAP group and control group(P=0.001).There was no significant difference in the levels of plasma MCP-1 between SAP and control group(P>0.05).There was no significant difference in the levels of plasma MCP-1 among patients with one,two or three diseased coronary vessels(P<0.05).Plasma level of MCP-1 was positively correlated with cTnⅠ(r=0.371,P=0.010),and negtively correlated with apoAⅠ(r=-0.233,P=0.007).Conclusion Plasma MCP-1 level is significantly elevated in ACS,indicating its role as a marker predicting the unstability of plaques.
Pages: 170-173
Year: 2008 Issue: 3
Journal: Railway Medical Journal
Keyword: premature coronary heart disease; monocyte chemoattractant protein-1; acute coronary syndrome; stable angina pectoris;
Abstract: Objective To study the relationship between plasma concentration of monocyte chemoattractant protein-1(MCP-1)and patients with premature heart disease.Methods MCP-l was measured by means of enzyme linked immonosorbent assay(ELISA)in 44 patients with acute coronary syndrome(ACS),41 patients with stable angina pectoris(SAP)and 87 patients in control group.Results Plasma concentration of MCP-1 was significantly higher in ACS group than that in SAP group and control group(P=0.001).There was no significant difference in the levels of plasma MCP-1 between SAP and control group(P>0.05).There was no significant difference in the levels of plasma MCP-1 among patients with one,two or three diseased coronary vessels(P<0.05).Plasma level of MCP-1 was positively correlated with cTnⅠ(r=0.371,P=0.010),and negtively correlated with apoAⅠ(r=-0.233,P=0.007).Conclusion Plasma MCP-1 level is significantly elevated in ACS,indicating its role as a marker predicting the unstability of plaques.
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