Analysis on Flt_3 internal tandem duplication mutation in malignant hematopoietic diseases
Author(s): GAO Sujun, LI Zuo, YANG Fang, WANG Guanjun
Pages: 591-592,607
Year: 2004 Issue: 4
Journal: Journal of Norman Bethune University of Medical Sc
Keyword: Flt 3 gene; leukemia; polymerase chain reaction; mutation;
Abstract: Objective To investigate Flt 3 tandem duplication mutation (ITD) and its distribution in different malignant hematopoietic diseases. Methods PCR was used to detect the Flt 3-ITD mutation in blast cell of bone marrow from 103 patients with malignant hematopoietic disease. Results Flt 3-ITD mutations were found in 18.2% (8/44)of the patients with primary acute myeloid leukemia (AML), more Flt 3 aberrations were found in patients with FAB M1. Flt 3-ITD mutations were not found in patients with acute lymphoid leukemia (ALL), myelodysplastic syndrome(MDS), multiple myeloma(MM), non-Hodgkin′s lymphoma(NHL), and chronic myeloid leukemia (CML). Conclusion Flt 3-ITD can be a important molecular marker for AML.
Pages: 591-592,607
Year: 2004 Issue: 4
Journal: Journal of Norman Bethune University of Medical Sc
Keyword: Flt 3 gene; leukemia; polymerase chain reaction; mutation;
Abstract: Objective To investigate Flt 3 tandem duplication mutation (ITD) and its distribution in different malignant hematopoietic diseases. Methods PCR was used to detect the Flt 3-ITD mutation in blast cell of bone marrow from 103 patients with malignant hematopoietic disease. Results Flt 3-ITD mutations were found in 18.2% (8/44)of the patients with primary acute myeloid leukemia (AML), more Flt 3 aberrations were found in patients with FAB M1. Flt 3-ITD mutations were not found in patients with acute lymphoid leukemia (ALL), myelodysplastic syndrome(MDS), multiple myeloma(MM), non-Hodgkin′s lymphoma(NHL), and chronic myeloid leukemia (CML). Conclusion Flt 3-ITD can be a important molecular marker for AML.
Related Articles