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esophagus,cardia of stomach
Pages: 43-45
Year: Issue:  2
Journal: China Medical Abstracts

Abstract: 209244 Long-term effects of radical resection plus interstitial implantation of 125Ⅰ radioactive seeds in the treatment of cancer of cardia/Zhang Jijun(Dept Thorac Surg,359 Hosp PLA,Zhenjiang 212001)…∥Chin J Thorac Cardiovasc Surg.-2009,25(1).-2628Objective To evaluate the long-term effect of interstitial implantation of radioactive iodine-125(125Ⅰ)seeds as an adjunctive technique to the radical resection in the treatment of cancer of cardia.Methods From March 2001 to March 2003,one hundred and eighteen patients with cancer of cardia underwent radial resection in our depatment.Fifty-seven patients(group A)were treated with resection plus interstitial implanttion of radioactive 125Ⅰ seeds during surgery,and 61 patients(group B) were treated with radical resection along.The rate of 3-year and 5-year survival,postoperative complications and mortality were compared between the two groups.Results The demographic data of the two groups were comparable,as well as metastatic status of the lymph nodes,cancer staging,and the type of operation.One hundred and thirteen patients were followed for 5 years.The overall rate of follow up was 95.8%,96.5% in group A and 95.1% in group B.The differences in the rates of 3-year and 5-year survival between group A(59.6% and 49.1%) and group B(41.0% AND 31.1%)were statistically significant(χ2=4.072,P<0.05,for the rate of 3-year survival;χ2=3.939,P<0.05,for the rate of 5-year survival).Postoperative complications,including anastomotic stricture,pancreatic fistula,anastomotic leakage,ileus and pulmonary infection,occurred in 5 patients of group A and in 4 patients of group B.The patients died postperatively,1 in group A and 2 in group B.The differences in the rates of postoperative complications and mortality between group A(8.8% and 1.8%)and group B(6.6% and 3.3%)were not statistically significant(χ2=0.111,P<0.05,for the rate of postoperative complications;χ2=0.333,P<0.05,for the mortality rate).There were 26 and 37 deaths in group A and B respectively.Six deaths in group A and 13 deaths in group B were attributed to local recurrence,and 17 deaths in group A and 21 deaths in group B were attributed to remote metastasis.Non-neoplasma diseases such as vascular events,diabetes mellitus,pulmonary infection and severe malnutrition were the causes of 3 deaths in each group.
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