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Effects of rosiglitazone on the apoptosis of smooth muscle cells and the protein expressions of the Bcl-2/Bax after balloon denudation of iliac artery in rabbits
Author(s): 
Pages: 2643-2645
Year: Issue:  16
Journal: The Journal of Practical Medicine

Keyword:  再灌注损伤罗格列酮细胞凋亡Bcl-2蛋白Bax蛋白;
Abstract: 目的:观察罗格列酮时兔髂动脉球囊内膜剥脱术后细胞凋亡及凋亡调控蛋白Bcl-2、Bax表达的影响.方法:将30只雄性新西兰大耳白兔随机分为3组,正常对照组(普通饮食)、模型组(高脂饮食+球囊内膜剥脱术)和罗格列酮组(高脂饮食+球囊内膜剥脱术+罗格列酮).分别于术后第1、4周末处死动物,取髂动脉标本行病理形态学观察,TUNEL法检测细胞凋亡水平,免疫组化法测定Bax、Bcl-2蛋白表达的情况.结果:正...
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