Author(s): ZHAO Jiangpei, ZHANG Rufu, JIA Hongxing
Pages: 1354-1357
Year: 2009 Issue:  10
Journal: Journal of Chinese Physician
Keyword:  Ferulic acid/PD; Diabetes mellitus/ME; Transforming growth factor beta/ME; Collagen type W/ME;
Abstract: 目的 探讨阿魏酸钠(SF)对糖尿病(DM)大鼠肾脏转化生长因子-β1(TGF-β1)和Ⅳ型胶原表达的影响.方法 Wistar大鼠随机分为正常时照组、DM对照组、SF治疗组,制备链脲佐菌素(STZ)诱导的DM大鼠模型,SF治疗组灌胃给予SF 110ms/(kg·d),治疗8周.分别测定各组大鼠肾重/体重、肌酐清除率(Ccr)、24 h尿蛋白定量,观察肾脏病理改变并用免疫组织化学方法检测肾脏TGF-β...