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Effect of heparin upon inflammatory reaction of endotoxin-induced acute lung injury in rat
Pages: 2722-2725
Year: Issue:  38
Journal: National Medical Journal of China

Keyword:  HeparinEndotoxinsAcute lung injuryInflammationRats;
Abstract: 目的 探讨肝素对内毒索诱导急性肺损伤(ALI)大鼠炎症反应的影响及其相关机制.方法 36只清洁级雄性SD大鼠按随机数字表法分为ALI组、肝素治疗组(肝素组)和正常对照组(对照组),每组12只.内毒素静脉注射复制大鼠ALI模型.建模后4 h处死各组大鼠,采用改良Smith评分法进行肺组织形态学评分,单核素示踪技术测定肺微血管白蛋白通透性(Palb),酶联免疫吸附试验测定血清中肿瘤坏死因子α(TNF-...
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