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Effects of gentian violet on virulent properties of Candida albicans
Author(s): 
Pages: 648-650
Year: Issue:  9
Journal: China journal of Leprosy and Skin Diseases

Keyword:  念珠菌甲紫磷脂酶蛋白酶芽管生成率;
Abstract: 目的:确定甲紫对白念珠菌毒力因子分泌型酸性蛋白酶和细胞外磷脂酶活性及芽管生成率的作用.方法:采用蛋黄平皿培养基和小牛血清白蛋白培养基分别检测筛选蛋白酶、磷脂酶阳性且Pz值≥2+的白念珠菌各12株,将2 μg/mL、0.5 μg/mL的甲紫溶液作用于各菌株菌悬液1 h.分别测定不同浓度甲紫溶液作用前后各菌株蛋白酶、磷脂酶的Pz值及芽管生成率,比较甲紫溶液作用前后各菌株蛋白酶、磷脂酶活性及芽管生成率的不同.结果:2 μg/mL、0.5 μg/mL药物作用组磷脂酶活性、蛋白酶活性及芽管生成率均显著低于药物作用前对照组(P<0.05).结论:低浓度甲紫溶液短时间作用于白念珠菌可降低菌株磷脂酶、蛋白酶活性和芽管生成率,从而降低白念珠菌毒力和致病性.
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