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Effect of fluvastatin on the proliferation of fibroblasts and collagen secretion in systemic sclerosis
Author(s): 
Pages: 645-647
Year: Issue:  9
Journal: China journal of Leprosy and Skin Diseases

Keyword:  系统性硬皮病氟伐他汀成纤维细胞;
Abstract: 目的:确定氟伐他汀对系统性硬皮病(systemic scleroderma,SS)皮肤成纤维细胞(fibroblasts,Fb)增殖及胶原分泌的影响.方法:原代培养SS患者皮肤Fb 72 h,四甲基偶氮唑盐(MTT)比色法检测不同浓度的氟伐他汀对细胞的存活力,并绘制不同浓度氟伐他汀作用下Fb的生长曲线;观察不同浓度的氟伐他汀对Fb胶原分泌的影响.结果:与空白对照组相比,各浓度的氟伐他汀均明显抑制患者皮肤Fb的增殖,使细胞的生长速度减慢,显著减少Fb培养液中可溶性胶原的含量,差异有显著性(P<0.05),且随着药物浓度的增高而增强,具有明显的浓度依赖性.结论:氟伐他汀对SS皮肤Fb的增殖及胶原的分泌均有显著抑制作用,为其治疗硬皮病提供了理论基础.
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