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5-Hydroxytryptamine and Visceral Hypersensitivity in Irritable Bowel Syndrome
Author(s): 
Pages: 502-504
Year: Issue:  8
Journal: Chinese Journal of Gastroenterology

Keyword:  血清素受体血清素肠易激综合征内脏高敏感性;
Abstract: 肠易激综合征(IBS)是一种常见的功能性胃肠病,由于缺少明确的结构和生化改变,其临床诊断和治疗均有一定难度.目前认为内脏高敏感性和胃肠道动力异常是IBS的病理生理基础.近年来探索内脏高敏感性的形成机制成为IBS研究的热点.研究显示5-羟色胺(5-HT)可能与内脏高敏感性相关.5-HT相关制剂用于IBS的治疗已取得一定疗效.5-HT在内脏高敏感性形成机制中作用的研究将有助于IBS病理生理机制的阐明和临床新药的开发.
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